Scutellarin inhibits the uninduced and metal-induced aggregation of α-Synuclein and disaggregates preformed fibrils: implications for Parkinson's disease
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منابع مشابه
Rifampicin Inhibits -Synuclein Fibrillation and Disaggregates Fibrils
mentia development if they had been under antileprosy The aggregation of -synuclein in dopaminergic neutreatment with dapsone or rifampicin (Figure 1) and rons of the substantia nigra is a critical step in the closely related drugs for the preceding several years pathogenesis of Parkinson’s disease. We show that [22, 23]. For example, it has been shown that the overall the antibiotic rifampicin...
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Posttranslational modification of proteins by attachment of small ubiquitin-related modifier (SUMO) contributes to numerous cellular phenomena. Sumoylation sometimes creates and abolishes binding interfaces, but increasing evidence points to another role for sumoylation in promoting the solubility of aggregation-prone proteins. Using purified α-synuclein, an aggregation-prone protein implicated...
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Amyloid deposits from several human diseases have been found to contain membrane lipids. Co-aggregation of lipids and amyloid proteins in amyloid aggregates, and the related extraction of lipids from cellular membranes, can influence structure and function in both the membrane and the formed amyloid deposit. Co-aggregation can therefore have important implications for the pathological consequen...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2020
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bcj20190705